| Peyton Manning's Career Passing Stats Versus Each Team | ||||||||||
| Team | W | L | Att | Com | Pct | Yards | Yds/Att | Long | Td | Int | QB Rating |
| Arizona Cardinals | 2-0 | 32 | 21 | 65.6 | 336 | 10.5 | 72 | 4 | 1 | 127.0 |
| Atlanta Falcons | 3-1 | 124 | 89 | 71.7 | 1046 | 8.4 | 36 | 13 | 4 | 118.5 |
| Baltimore Ravens | 7-2 | 305 | 192 | 62.9 | 2443 | 8.0 | 67 | 17 | 8 | 95.5 |
| Buffalo Bills | 7-4 | 338 | 209 | 61.8 | 2345 | 6.9 | 50 | 13 | 10 | 83.0 |
| Carolina Panthers | 1-2 | 98 | 54 | 55.1 | 793 | 7.9 | 59 | 4 | 3 | 82.5 |
| Chicago Bears | 2-2 | 154 | 122 | 79.2 | 1017 | 6.6 | 53T | 8 | 3 | 103.3 |
| Cincinnati Bengals | 7-0 | 235 | 154 | 65.5 | 1827 | 7.7 | 69 | 17 | 3 | 107.8 |
| Cleveland Browns | 5-0 | 165 | 109 | 66.0 | 1124 | 6.8 | 51 | 2 | 3 | 81.9 |
| Dallas Cowboys | 2-2 | 159 | 107 | 67.2 | 1183 | 7.4 | 54 | 7 | 7 | 85.4 |
| Denver Broncos | 6-2 | 250 | 155 | 62.0 | 1645 | 6.5 | 63 | 15 | 5 | 92.8 |
| Detroit Lions | 3-0 | 98 | 73 | 74.4 | 842 | 8.5 | 39 | 10 | 2 | 125.4 |
| Green Bay Packers | 1-2 | 126 | 74 | 58.7 | 916 | 7.3 | 36T | 8 | 3 | 92.5 |
| Houston Texans | 16-2 | 668 | 448 | 67.0 | 5122 | 7.6 | 80T | 42 | 9 | 105.2 |
| Jacksonville Jaguars | 14-5 | 619 | 444 | 71.7 | 5241 | 8.4 | 76T | 38 | 13 | 108.8 |
| Kansas City Chiefs | 6-1 | 253 | 157 | 62.0 | 1911 | 7.5 | 56 | 10 | 8 | 85.2 |
| Miami Dolphins | 5-7 | 403 | 244 | 60.5 | 2957 | 7.3 | 80T | 18 | 18 | 60.5 |
| Minnesota Vikings | 3-0 | 97 | 74 | 76.2 | 862 | 8.8 | 58 | 9 | 3 | 120.7 |
| New England Patriots | 7-10 | 633 | 396 | 62.5 | 4712 | 7.4 | 78T | 37 | 24 | 88.9 |
| New Orleans Saints | 3-2 | 157 | 103 | 65.6 | 1485 | 9.4 | 86T | 12 | 5 | 86.6 |
| New York Giants | 3-1 | 148 | 101 | 68.2 | 1133 | 7.6 | 57T | 9 | 4 | 99.8 |
| New York Jets | 7-4 | 394 | 247 | 62.6 | 2695 | 6.8 | 41 | 13 | 11 | 78.4 |
| Oakland Raiders | 3-2 | 184 | 113 | 61.4 | 1261 | 6.8 | 50T | 12 | 8 | 85.4 |
| Philadelphia Eagles | 3-1 | 121 | 79 | 65.2 | 1031 | 8.5 | 80T | 8 | 3 | 103.7 |
| Pittsburgh Steelers | 2-2 | 151 | 90 | 59.6 | 1079 | 7.1 | 80T | 7 | 4 | 85.9 |
| San Diego Chargers | 4-4 | 362 | 224 | 61.8 | 2529 | 9.9 | 55 | 15 | 18 | 75.8 |
| San Francisco 49ers | 2-2 | 160 | 103 | 64.3 | 1203 | 7.5 | 61T | 5 | 6 | 81.4 |
| Seattle Seahawks | 2-2 | 122 | 83 | 68.0 | 1085 | 8.8 | 53 | 4 | 2 | 99.9 |
| St. Louis Rams | 2-1 | 104 | 60 | 57.6 | 621 | 5.9 | 36 | 5 | 1 | 87.0 |
| Tampa Bay Buccaneers | 2-0 | 84 | 63 | 75.0 | 639 | 7.6 | 52 | 3 | 2 | 98.2 |
| Tennessee Titans | 13-5 | 578 | 399 | 69.0 | 4559 | 7.8 | 68T | 31 | 13 | 100.9 |
| Washington Redskins | 3-1 | 142 | 94 | 66.1 | 1161 | 8.1 | 57T | 10 | 3 | 105.9 |
| Peyton Manning's Career Rushing Stats Versus Each Team | ||||||||
| Team | W | L | Att | Yards | Avg. | Td | Sacked | Yards | Fumbles |
| Arizona Cardinals | 2-0 | 1 | -1 | -1.0 | 0 | 1 | -4 | 0 |
| Atlanta Falcons | 3-1 | 5 | 17 | 3.4 | 0 | 5 | 34 | 0 |
| Baltimore Ravens | 7-2 | 15 | 26 | 1.7 | 0 | 12 | 91 | 1 |
| Buffalo Bills | 7-4 | 26 | 79 | 3.0 | 2 | 9 | 66 | 0 |
| Carolina Panthers | 1-2 | 1 | 6 | 6.0 | 0 | 5 | 19 | 0 |
| Chicago Bears | 2-2 | 5 | 26 | 6.5 | 0 | 5 | 46 | 1 |
| Cincinnati Bengals | 7-0 | 11 | 21 | 1.9 | 1 | 5 | 17 | 0 |
| Cleveland Browns | 5-0 | 14 | 36 | 2.5 | 0 | 2 | 10 | 0 |
| Dallas Cowboys | 2-2 | 8 | 11 | 1.3 | 0 | 3 | 20 | 1 |
| Denver Broncos | 6-2 | 20 | 21 | 1.0 | 0 | 3 | 14 | 3 |
| Detroit Lions | 3-0 | 3 | 7 | 2.3 | 0 | 2 | 10 | 0 |
| Green Bay Packers | 1-2 | 4 | -9 | -2.3 | 0 | 4 | 27 | 0 |
| Houston Texans | 16-2 | 37 | 32 | 1.1 | 0 | 23 | 140 | 2 |
| Jacksonville Jaguars | 14-5 | 42 | 30 | 0.7 | 3 | 15 | 102 | 2 |
| Kansas City Chiefs | 6-1 | 17 | 4 | 0.5 | 1 | 10 | 79 | 3 |
| Miami Dolphins | 5-7 | 20 | 61 | 3.0 | 2 | 18 | 124.5 | 0 |
| Minnesota Vikings | 3-0 | 7 | 19 | 2.7 | 0 | 3 | 19 | 0 |
| New England Patriots | 7-10 | 24 | 74 | 3.1 | 3 | 23 | 148 | 4 |
| New Orleans Saints | 2-2 | 6 | 15 | 2.5 | 0 | 5 | 26 | 0 |
| New York Giants | 3-1 | 6 | -6 | -1.0 | 0 | 4 | 25 | 0 |
| New York Jets | 7-4 | 23 | 96 | 4.1 | 1 | 13 | 76 | 0 |
| Oakland Raiders | 3-2 | 10 | 50 | 5.0 | 0 | 8 | 53 | 0 |
| Philadelphia Eagles | 3-1 | 6 | 23 | 3.8 | 0 | 4 | 26 | 0 |
| Pittsburgh Steelers | 2-2 | 1 | 10 | 10.0 | 0 | 70 | 1 | |
| San Diego Chargers | 4-4 | 10 | 6 | .6 | 1 | 12 | 659 | 1 |
| San Francisco 49ers | 2-2 | 1 | 0 | 0.0 | 0 | 6 | 30 | 0 |
| Seattle Seahawks | 2-2 | 2 | -1 | -0.5 | 0 | 3 | 6 | 0 |
| St. Louis Rams | 2-1 | 4 | 6 | 1.5 | 1 | 4 | 21 | 0 |
| Tampa Bay Buccaneers | 2-0 | 2 | -2 | -2.0 | 0 | 1 | 5 | 0 |
| Tennessee Titans | 13-5 | 20 | 55 | 2.7 | 1 | 13 | 80 | 2 |
| Washington Redskins | 3-1 | 4 | -2.0 | -0.5 | 1 | 5 | 34 | 2 |
